Grazoprevir

目录号: A17303
Hepatitis C virus NS3/4a protease inhibitor
Grazoprevir (MK-5172) 是一种选择性的乙型肝炎病毒 NS3/4a 蛋白酶抑制剂,具有广泛的活性,覆盖多个基因型和耐药变异体,其抑制常数 (Ki) 分别为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。
Grouped product items
规格 价格 库存 数量
1mg
¥245.00
现货
2mg
¥350.00
现货
5mg
¥595.00
现货
10mg
¥980.00
现货
25mg
¥1,925.00
现货
50mg
¥3,185.00
现货
100mg
¥4,900.00
现货
500mg
¥10,185.00
现货
10mM * 1mL in DMSO
¥840.00
现货
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重要通知:仅供研究使用。我们不向患者销售。

顾客使用 Adooq 产品发表的高质量科研文献
Adooq用户使用Grazoprevir发表的2篇文献
  • Deqiang Kong, .et al. , Nat Commun, 2024, Jun 8;15(1):4894 PMID: 38849338
  • Xinyi Wang, .et al. , Nat Chem Biol, 2023, Oct 23 PMID: 37872400
  • 生物活性
    Discription Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
    Cell Research
    Cell Line Type Value Description References
    产品信息
    目录号 A17303
    分子式 C38H50N6O9S
    分子量 766.9
    CAS号 1350514-68-9
    SMILES COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1
    其他名称 MK-5172, MK5172, MK 5172
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    溶解性数据
    In vitro DMSO 93 mg/mL (121.26 mM)
    Water Insoluble
    Ethanol 93 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 13.04 mL 65.2 mL 130.4 mL
    0.5 mM 2.61 mL 13.04 mL 26.08 mL
    1 mM 1.3 mL 6.52 mL 13.04 mL
    5 mM 0.26 mL 1.3 mL 2.61 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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