Grazoprevir

Name: Grazoprevir
SKU: A17303
Price: 245 CNY
Rating: 5 (2 reviews)

目录号: A17303

Hepatitis C virus NS3/4a protease inhibitor

2 篇发表文献

Grazoprevir (MK-5172) 是一种选择性的乙型肝炎病毒 NS3/4a 蛋白酶抑制剂，具有广泛的活性，覆盖多个基因型和耐药变异体，其抑制常数 (Ki) 分别为 0.01 nM (gt1b)、0.01 nM (gt1a)、0.08 nM (gt2a)、0.15 nM (gt2b)、0.90 nM (gt3a)。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥350.00	现货
5mg	¥595.00	现货
10mg	¥980.00	现货
25mg	¥1,925.00	现货
50mg	¥3,185.00	现货
100mg	¥4,900.00	现货
500mg	¥10,185.00	现货
*10mM 1mL in DMSO**	¥840.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Grazoprevir发表的2篇文献

Deqiang Kong, .et al. , Nat Commun, 2024, Jun 8;15(1):4894 PMID: 38849338

Xinyi Wang, .et al. , Nat Chem Biol, 2023, Oct 23 PMID: 37872400

生物活性

Discription

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A17303
分子式	C38H50N6O9S
分子量	766.9
CAS号	1350514-68-9
SMILES	COC1=CC2=C(N=C(CCCCC[C@@H]3C[C@H]3OC4=O)C(O[C@H]5CN(C([C@H](C(C)(C)C)N4)=O)[C@H](C(N[C@@]([C@@H]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1
其他名称	MK-5172, MK5172, MK 5172
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	93 mg/mL (121.26 mM)
	Water	Insoluble
	Ethanol	93 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.04 mL	65.2 mL	130.4 mL
0.5 mM	2.61 mL	13.04 mL	26.08 mL
1 mM	1.3 mL	6.52 mL	13.04 mL
5 mM	0.26 mL	1.3 mL	2.61 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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