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GS-9451是一种有效的大环HCV NS3 PI，在3天单药治疗后，HCV RNA的中值最大变化达到3.6 log10 IU/mL（范围从-4.7 log10到-3.1 log10 IU/mL）。 I期HCV基因型1感染。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.44 mL | 52.22 mL | 104.44 mL |
| 0.5 mM | 2.09 mL | 10.44 mL | 20.89 mL |
| 1 mM | 1.04 mL | 5.22 mL | 10.44 mL |
| 5 mM | 0.21 mL | 1.04 mL | 2.09 mL |
*The above data is based on the productmolecular weight 957.461. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13526 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 957.461 |
| Formula | C46H56ClF2N6O8PS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1001094-46-7 |
| Synonyms | GS 9256, GS9256 |
| SMILES | CC(C)NC1=NC(=CS1)C2=NC3=C(C=CC(=C3Cl)OC)C(=C2)O[C@@H]4C[C@H]5C(=O)N[C@@]6(C[C@H]6CCCCCCC[C@@H](C(=O)N5C4)NC(=O)OC7CCCC7)P(=O)(CC8=C(C=CC=C8F)F)O |
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