GSK 5959
目录号: A16092
BRPF1 bromodomain inhibitor
GSK 5959 是一种强效、选择性且能渗透细胞的 BRPF1 溴结构域抑制剂，IC50 约为 80 nM。对 BRPF1 的选择性超过其他35种溴结构域100倍以上，包括 BRPF2/3 和 BET 家族溴结构域。
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生物活性
| Discription | GSK 5959 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM. Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. | |||||
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| Cell Research |
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产品信息
| 目录号 | A16092 |
|---|---|
| 分子式 | C22H26N4O3 |
| 分子量 | 394.48 |
| CAS号 | 901245-65-6 |
| SMILES | O=C(NC1=C(N2CCCCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
| 其他名称 | GSK-5959, GSK5959 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 5 mg/mL (12.68 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (7.6 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.35 mL | 126.75 mL | 253.5 mL |
| 0.5 mM | 5.07 mL | 25.35 mL | 50.7 mL |
| 1 mM | 2.53 mL | 12.67 mL | 25.35 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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