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GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。
靶点信息
| PI3Kα | PI3Kβ | PI3Kδ | PI3Kγ | mTOR |
| 0.4 nM | 0.6 nM | 2 nM | 5 nM | 12 nM |
| In vitro | DMSO | 2 mg/mL (5.99 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.99 mL | 149.97 mL | 299.94 mL |
| 0.5 mM | 6 mL | 29.99 mL | 59.99 mL |
| 1 mM | 3 mL | 15 mL | 29.99 mL |
| 5 mM | 0.6 mL | 3 mL | 6 mL |
*The above data is based on the productmolecular weight 333.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10438 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 333.4 |
| Formula | C18H11N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 958852-01-2 |
| Synonyms | GSK-1059615 |
| SMILES | C1=CC2=NC=CC(=C2C=C1/C=C\3/C(=O)NC(=O)S3)C4=CC=NC=C4 |
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