GSK126

Name: GSK126
SKU: A11757
Price: 210 CNY
Rating: 5 (4 reviews)

目录号: A11757

EZH2 抑制剂

4 篇发表文献

GSK126 是一种高效、高选择性的 S-腺苷甲硫氨酸竞争性小分子抑制剂，针对 EZH2 甲基转移酶活性，能够降低全局 H3K27me3 水平并重新激活被沉默的 PRC2 目标基因。

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Grouped product items
规格	价格	库存
2mg	¥210.00	现货
5mg	¥350.00	现货
10mg	¥595.00	现货
25mg	¥1,015.00	现货
50mg	¥1,610.00	现货
100mg	¥2,520.00	现货
200mg	¥3,290.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用GSK126发表的4篇文献

Lucy E. Dawson, .et al. , Sarcoma, 2020, 2020: 8647981 PMID: 32300280

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Dupret B, .et al. , Biochim Biophys Acta Gene Regul Mech, 2017, Oct;1860(10):1079-1093 PMID: 28887218

Theresa Baker, .et al. , Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609

生物活性

Discription

GSK126 is a potent, highly selective, S-adenosyl-methionine-competitive, small-molecule inhibitor of EZH2 methyltransferase activity, decreases global H3K27me3 levels and reactivates silenced PRC2 target genes.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11757
分子式	C31H38N6O2
分子量	526.67
CAS号	1346574-57-9
SMILES	CC[C@H](C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
其他名称	GSK 126, GSK-126
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 3 mg/mL (5.69 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+corn oil	0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.99 mL	94.94 mL	189.87 mL
0.5 mM	3.8 mL	18.99 mL	37.97 mL
1 mM	1.9 mL	9.49 mL	18.99 mL
5 mM	0.38 mL	1.9 mL	3.8 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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