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GSK1324726A (I-BET726)

GSK1324726A (I-BET726)

Name: GSK1324726A (I-BET726)
SKU: A14133

目录号: A14133

BET 抑制剂

Product Citations (1)

GSK1324726A (I-BET726) Chemical Structure

CAS NO. 1300031-52-0

GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂，对BRD2（IC50 = 41 nM）、BRD3（IC50 = 31 nM）和BRD4（IC50 = 22 nM）具有高度的亲和力。

库存：现货

规格	价格	数量
5 mg	￥ 728.00
10 mg	￥ 1,239.00
25 mg	￥ 2,184.00
10mM * 1mL in DMSO	￥ 1,155.00

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生物活性

GSK1324726A (I-BET726)是一种新型、高效、选择性的BET蛋白小分子抑制剂，对BRD2（IC50 = 41 nM）、BRD3（IC50 = 31 nM）和BRD4（IC50 = 22 nM）具有高度的亲和力。

靶点信息

BRD4	BRD3	BRD2
22 nM	31 nM	41 nM

溶解度 *

In vitro	DMSO	77 mg/mL (177.05 mM)
	Water	Insoluble
	Ethanol	77 mg/mL (177.05 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.99 mL	114.97 mL	229.93 mL
0.5 mM	4.6 mL	22.99 mL	45.99 mL
1 mM	2.3 mL	11.5 mL	22.99 mL
5 mM	0.46 mL	2.3 mL	4.6 mL

*The above data is based on the productmolecular weight 434.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A14133
作用机制	Inhibitor (抑制剂)
M. Wt	434.91
Formula	C25H23ClN2O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1300031-52-0
Synonyms	I-BET726, GSK 1324726A, GSK-1324726A, I-BET 726
SMILES	CC1CC(C2=C(N1C(=O)C)C=CC(=C2)C3=CC=C(C=C3)C(=O)O)NC4=CC=C(C=C4)Cl