GSK2141795 (Uprosertib, GSK795)

Name: GSK2141795 (Uprosertib, GSK795)
SKU: A15809
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A15809

Akt inhibitor

Akt 抑制剂 GSK2141795 与 Akt 结合并抑制其活性，这可能导致抑制 PI3K/Akt 信号通路和肿瘤细胞增殖，并诱导肿瘤细胞凋亡。

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
2mg	¥315.00	现货
5mg	¥490.00	现货
10mg	¥840.00	现货
25mg	¥1,435.00	现货
50mg	¥2,345.00	现货
100mg	¥3,885.00	现货
200mg	¥5,495.00	现货
*10mM 1mL in DMSO**	¥735.00	现货
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Data Sheet

SDS

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生物活性

Discription

Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.

Targets

Cell Research

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Cell Line	Type	Value	Description	References
HCT-116	IC50	0.72 μM	Antiproliferative activity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 31298542]
HCT-116	IC50	1.75 μM	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31301565]
LNCaP	IC50	75.63 nM	Inhibition of Akt in human PTEN-null LNCAP cells assessed as suppression in PRAS40 phosphorylation after 1 hr by ELISA analysis	[PMID: 27089211]
OVCAR-8	IC50	0.54 μM	Cytotoxicity against human OVCAR8 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 31301565]

Showing 1 to 4 of 4 entries

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产品信息

目录号	A15809
分子式	C18H16Cl2F2N4O2
分子量	429.25
CAS号	1047634-65-0
SMILES	CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl
其他名称	GSK2141795, GSK2141795, Uprosertib, GSK 795
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	80 mg/mL (186.36 mM)
	Water	Insoluble
	Ethanol	80 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.3 mL	116.48 mL	232.96 mL
0.5 mM	4.66 mL	23.3 mL	46.59 mL
1 mM	2.33 mL	11.65 mL	23.3 mL
5 mM	0.47 mL	2.33 mL	4.66 mL

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