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GSK2141795 (Uprosertib,GSK795)结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导。
靶点信息
| Akt3 | Akt1 | Akt2 | ||
| 38 nM | 180 nM | 328 nM |
| In vitro | DMSO | 80 mg/mL (186.36 mM) | |
| Water | Insoluble | ||
| Ethanol | 80 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.3 mL | 116.48 mL | 232.96 mL |
| 0.5 mM | 4.66 mL | 23.3 mL | 46.59 mL |
| 1 mM | 2.33 mL | 11.65 mL | 23.3 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15809 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 429.25 |
| Formula | C18H16Cl2F2N4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1047634-65-0 |
| Synonyms | GSK2141795, GSK2141795, Uprosertib, GSK 795 |
| SMILES | CN1C(=C(C=N1)Cl)C2=C(OC(=C2)C(=O)NC(CC3=CC(=C(C=C3)F)F)CN)Cl |
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