产品详情

生物活性

GSK256066是PDE4的极高亲和力和选择性抑制剂，它以相等的亲和力抑制PDE4亚型A-D，并具有很高的HARBS（高亲和力利普兰结合位点）比率（> 17）。

靶点信息

PDE4B
3.2 pM

溶解度 *

In vitro (25°C)	DMSO	4 mg/mL (7.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.28 mL	96.41 mL	192.83 mL
0.5 mM	3.86 mL	19.28 mL	38.57 mL
1 mM	1.93 mL	9.64 mL	19.28 mL
5 mM	0.39 mL	1.93 mL	3.86 mL

*The above data is based on the productmolecular weight 518.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11073
作用机制	Inhibitor (抑制剂)
M. Wt	518.6
Formula	C27H26N4O5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	801312-28-7
Synonyms	GSK-256066
SMILES	CC1=C2C(=CC(=C1)S(=O)(=O)C3=CC=CC(=C3)C(=O)N(C)C)C(=C(C=N2)C(=O)N)NC4=CC(=CC=C4)OC