GSK2578215A
目录号: A12798
LRRK2 kinase 抑制剂
GSK2578215A 是一种强效的富含亮氨酸重复激酶 2(LRRK2)抑制剂(对于 LRRK2[G2019S] 突变体和野生型 LRRK2 的 IC50 值分别为 8.9 nM 和 10.1 nM)。
Discription | GSK2578215A is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor (IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively). | ||
---|---|---|---|
Targets |
|
目录号 | A12798 |
---|---|
分子式 | C24H18FN3O2 |
分子量 | 399.42 |
CAS号 | 1285515-21-0 |
SMILES | C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4 |
其他名称 | GSK-2578215A, GSK 2578215A |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | Warmed: 73 mg/mL (182.76 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 25.04 mL | 125.18 mL | 250.36 mL |
0.5 mM | 5.01 mL | 25.04 mL | 50.07 mL |
1 mM | 2.5 mL | 12.52 mL | 25.04 mL |
5 mM | 0.5 mL | 2.5 mL | 5.01 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2