GSK2578215A

Name: GSK2578215A
SKU: A12798

目录号: A12798

LRRK2 kinase 抑制剂

GSK2578215A Chemical Structure

CAS NO. 1285515-21-0

GSK2578215A是一种有效的富含亮氨酸的重复激酶2（LRRK2）抑制剂（LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM）。

库存：现货

规格	价格	数量
10 mg	￥ 420.00
25 mg	￥ 840.00
50 mg	￥ 1,610.00
100 mg	￥ 2,800.00
10mM * 1mL in DMSO	￥ 609.00

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生物活性

GSK2578215A是一种有效的富含亮氨酸的重复激酶2（LRRK2）抑制剂（LRRK2 [G2019S]突变体和野生型LRRK2的IC50值分别为8.9和10.1 nM）。

靶点信息

LRRK2 (G2019S)	LRRK2 (WT)
8.9 nM	10.9 nM

溶解度 *

In vitro	DMSO	Warmed: 73 mg/mL (182.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.04 mL	125.18 mL	250.36 mL
0.5 mM	5.01 mL	25.04 mL	50.07 mL
1 mM	2.5 mL	12.52 mL	25.04 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12798
作用机制	Inhibitor (抑制剂)
M. Wt	399.42
Formula	C24H18FN3O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1285515-21-0
Synonyms	GSK-2578215A, GSK 2578215A
SMILES	C1=CC=C(C=C1)COC2=C(C=C(C=C2)C3=CC(=NC=C3)F)C(=O)NC4=CN=CC=C4