GSK343

Name: GSK343
SKU: A13114
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A13114

EZH2 抑制剂

2 篇发表文献

GSK343 是一种强效的组蛋白 H3-赖氨酸 27 (H3K27) 甲基转移酶 EZH2 抑制剂（IC50 = 4 nM）。对其他 HMTs 有1000倍的选择性，除了 EZH1（60倍选择性）。GSK343 在 HCC1806 细胞中抑制 H3K27 甲基化，IC50 <200nM（通过免疫荧光测定）。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥315.00	现货
10mg	¥525.00	现货
25mg	¥1,015.00	现货
50mg	¥1,715.00	现货
100mg	¥3,220.00	现货
*10mM 1mL in DMSO**	¥420.00	现货
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Data Sheet

SDS

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Adooq用户使用GSK343发表的2篇文献

Yang PM, .et al. , Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078

Nie L, .et al. , Nat Commun, 2019, Nov 8;10(1):5114 PMID: 31704972

生物活性

Discription

GSK343 is a potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC= 4 nM). Diplays 1000-fold selectivity for other HMTs except EZH1 (60-fold selectivity). GSK343 inhibits H3K27 methylation in HCC1806 cells with an IC of <200nM (measured by immunofluorescence).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13114
分子式	C31H39N7O2
分子量	541.69
CAS号	1346704-33-3
SMILES	CCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C
其他名称	GSK-343, GSK 343
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 1 mg/mL (1.84 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.54 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.46 mL	92.3 mL	184.61 mL
0.5 mM	3.69 mL	18.46 mL	36.92 mL
1 mM	1.85 mL	9.23 mL	18.46 mL
5 mM	0.37 mL	1.85 mL	3.69 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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