GSK429286A
目录号: A10441
ROCK 抑制剂
GSK429286A 是一种细胞渗透性、选择性的小分子抑制剂，专门针对 Rho-associated, coiled-coil containing protein kinase (ROCK)。
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生物活性
| Discription | GSK429286A is a cell-permeable, selective small molecule inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). | ||
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产品信息
| 目录号 | A10441 |
|---|---|
| 分子式 | C21H16F4N4O2 |
| 分子量 | 432.4 |
| CAS号 | 864082-47-3 |
| SMILES | CC1=C(C(CC(=O)N1)C2=CC=C(C=C2)C(F)(F)F)C(=O)NC3=C(C=C4C(=C3)C=NN4)F |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 81 mg/mL (187.33 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (9.25 mM) | ||
| In vivo | 15% Captisol+citrate vehicle | 14 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.13 mL | 115.63 mL | 231.27 mL |
| 0.5 mM | 4.63 mL | 23.13 mL | 46.25 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.13 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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