GSK481

Name: GSK481
SKU: A12615

目录号: A12615

RIP1 抑制剂

GSK481 Chemical Structure

CAS NO. 1622849-58-4

GSK481是新型的RIP1抑制剂苯并a庚酮（BOAz）系列。受体相互作用蛋白激酶1（RIP1）已被认为是通过调节程序性坏死调节炎症的关键因素。已显示对该激酶的抑制作用可阻止细胞坏死，从而将RIP1确定为潜在治疗多种炎性疾病的可行靶标。

库存：现货

规格	价格	数量
5 mg	￥ 700.00
10 mg	￥ 1,050.00
25 mg	￥ 1,960.00

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产品详情

生物活性

靶点信息

RIP1

溶解度 *

In vitro	DMSO	70 mg/mL (185.48 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.5 mL	132.49 mL	264.98 mL
0.5 mM	5.3 mL	26.5 mL	53 mL
1 mM	2.65 mL	13.25 mL	26.5 mL
5 mM	0.53 mL	2.65 mL	5.3 mL

*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12615
作用机制	Inhibitor (抑制剂)
M. Wt	377.39
Formula	C21H19N3O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1622849-58-4
Synonyms	GSK 481, GSK-481
SMILES	O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O