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GSK481

目录号: A12615
RIP1 抑制剂
GSK481 是一种新型的苯并噁唑酮(BOAz)系列的 RIP1 抑制剂受体相互作用蛋白激酶1(RIP1)被认为是通过调节程序性坏死来促进炎症的关键因素。抑制这种激酶已被证明可以阻碍细胞坏死性死亡,从而确定 RIP1 作为多种炎症性疾病潜在治疗的可行靶点。
Grouped product items
规格 价格 库存 数量
2mg
¥175.00
现货
5mg
¥245.00
现货
10mg
¥455.00
现货
25mg
¥875.00
现货
50mg
¥1,470.00
现货
100mg
¥2,380.00
现货
10mM * 1mL in DMSO
¥280.00
现货
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生物活性
Discription GSK481 is a novel benzoxazepinone (BOAz) series of RIP1 inhibitors. Receptor Interacting Protein Kinase 1 (RIP1) has been implicated as a key contributor to inflammation through the regulation of programmed necrosis. Inhibition of this kinase has been shown to hinder cell necrotic death, thereby establishing RIP1 as a viable target for the potential treatment of multiple inflammatory diseases.
Targets
Target Value
Cell Research
Cell Line Type Value Description References
产品信息
目录号 A12615
分子式 C21H19N3O4
分子量 377.39
CAS号 1622849-58-4
SMILES O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O
其他名称 GSK 481, GSK-481
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据
In vitro DMSO 70 mg/mL (185.48 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.5 mL 132.49 mL 264.98 mL
0.5 mM 5.3 mL 26.5 mL 53 mL
1 mM 2.65 mL 13.25 mL 26.5 mL
5 mM 0.53 mL 2.65 mL 5.3 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2

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