GSK591
目录号: A14374
PRMT5 抑制剂
GSK591 是一种强效的选择性抑制剂，针对精氨酸甲基转移酶 PRMT5，其半抑制浓度（IC50）为 11 nM。
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生物活性
| Discription | GSK591 is a potent selective inhibitor of the arginine methyltransferase PRMT5 with IC50 of 11 nM. | |||||
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| Cell Research |
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产品信息
| 目录号 | A14374 |
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| 分子式 | C22H28N4O2 |
| 分子量 | 380.48 |
| CAS号 | 1616391-87-7 |
| SMILES | O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4CCC4)=NC=C3 |
| 其他名称 | EPZ015866,GSK3203591 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 75 mg/mL (197.11 mM) | |
| Water | Insoluble | ||
| Ethanol | 75 mg/mL (197.11 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.28 mL | 131.41 mL | 262.83 mL |
| 0.5 mM | 5.26 mL | 26.28 mL | 52.57 mL |
| 1 mM | 2.63 mL | 13.14 mL | 26.28 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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