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GSK6853是BRPF1溴结构域的有效和选择性抑制剂。与所有其他溴结构域相比，它显示出优异的BRPF1效能（pKd 9.5）和大于1600倍的选择性。
| In vitro | DMSO | Warmed: 77 mg/mL (188.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 77 mg/mL (188.04 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.42 mL | 122.11 mL | 244.21 mL |
| 0.5 mM | 4.88 mL | 24.42 mL | 48.84 mL |
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
*The above data is based on the productmolecular weight 409.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16330 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 409.48 |
| Formula | C22H27N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1910124-24-1 |
| Synonyms | GSK-6853, GSK 6853 |
| SMILES | O=C(NC1=C(N2[C@H](C)CNCC2)C=C(N3C)C(N(C)C3=O)=C1)C4=CC=CC=C4OC |
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