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GW4064是选择性的非甾体类法尼醇X受体（FXR）激动剂（EC50 = 15 nM）。
靶点信息
| FXR (CV1) | ||||
| 65 nM(EC50) |
| In vitro (25°C) | DMSO | 99 mg/mL (182.37 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% methylcellulose | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.42 mL | 92.11 mL | 184.23 mL |
| 0.5 mM | 3.68 mL | 18.42 mL | 36.85 mL |
| 1 mM | 1.84 mL | 9.21 mL | 18.42 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.68 mL |
*The above data is based on the productmolecular weight 542.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11141 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 542.8 |
| Formula | C28H22Cl3NO4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 278779-30-9 |
| Synonyms | GW-4064 |
| SMILES | CC(C)C1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)COC3=CC(=C(C=C3)/C=C/C4=CC(=CC=C4)C(=O)O)Cl |
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