Hesperadin
Hesperadin 是一种针对人类 Aurora B 的抑制剂，其 IC50 值为 40 nM，用于防止底物的磷酸化。它显著降低了 AMPK、Lck、MKK1、MAPKAP-K1、CHK1 和 PHK 的活性，但在体内不抑制 MKK1 的活性。
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生物活性
| Discription | Hesperadin is a human Aurora B inhibitor with an IC50 of 40 nM for the prevention of the phosphorylation of substrate. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. | ||
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产品信息
| 目录号 | A10448 |
|---|---|
| 分子式 | C29H32N4O3S |
| 分子量 | 516.7 |
| CAS号 | 422513-13-1 |
| SMILES | CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 100 mg/mL (193.55 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 2.3 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.35 mL | 96.77 mL | 193.54 mL |
| 0.5 mM | 3.87 mL | 19.35 mL | 38.71 mL |
| 1 mM | 1.94 mL | 9.68 mL | 19.35 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.87 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 422513-13-1 | 422513-13-1 供应商 | 422513-13-1 花费 | 422513-13-1 生产商 | 订购 422513-13-1 | 422513-13-1 代理商