Hesperadin

Name: Hesperadin
SKU: A10448

目录号: A10448

Aurora B Kinase 抑制剂

Product Citations (1)

Hesperadin Chemical Structure

CAS NO. 422513-13-1

Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。

库存：现货

规格	价格	数量
5 mg	￥ 378.00
10 mg	￥ 644.00
50 mg	￥ 1,890.00
100 mg	￥ 6,426.00
10mM * 1mL in DMSO	￥ 1,064.00

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生物活性

Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。

靶点信息

TbAUK1 (Cell-free assay)	Aurora B (human) (Cell-free assay)
40 nM	250 nM

溶解度 *

In vitro (25°C)	DMSO	100 mg/mL (193.55 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40%PEG300+5% tween80+50% H2O	2.3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.35 mL	96.77 mL	193.54 mL
0.5 mM	3.87 mL	19.35 mL	38.71 mL
1 mM	1.94 mL	9.68 mL	19.35 mL
5 mM	0.39 mL	1.94 mL	3.87 mL

*The above data is based on the productmolecular weight 516.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10448
作用机制	Inhibitor (抑制剂)
M. Wt	516.7
Formula	C29H32N4O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	422513-13-1
SMILES	CCS(=O)(=O)NC1=CC\2=C(C=C1)NC(=O)/C2=C(/C3=CC=CC=C3)\NC4=CC=C(C=C4)CN5CCCCC5