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HIF-2a Translation Inhibitor（IC50值为5 uM）；独立于HIF-2a mRNA表达或HIF-2a蛋白稳定性，并独立于mTOR活性，降低常氧和低氧状态下HIF-2a蛋白和HIF-2a目标基因的表达。此外，翻译抑制剂76增强了IRP1与HIF-2a IRE（铁反应元件）的结合。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.81 mL | 174.03 mL | 348.06 mL |
| 0.5 mM | 6.96 mL | 34.81 mL | 69.61 mL |
| 1 mM | 3.48 mL | 17.4 mL | 34.81 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
*The above data is based on the productmolecular weight 287.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16181 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 287.31 |
| Formula | C9H9N3O4S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 882268-69-1 |
| SMILES | COC(=O)C1=C(C=CS1)NN=C(C#N)S(=O)(=O)C |
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