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HDAC

Inhibitory Selectivity

Catalog No.Inhibitor Name HDAC HDAC1 HDAC2 HDAC3 HDAC4HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2
A10979Vorinostat
****
A10611Entinostat
**
*
A10518Panobinostat
****
A10947Trichostatin A
****
A10586Mocetinostat
**
**
*
*
A10122Belinostat
***
A11920Romidepsin
***
***
A10560MC1568
*
A11042Tubastatin A HCl
*
***
A10488Givinostat
****
****
A10516Dacinostat
***
A10246CUDC-101
****
****
***
****
***
***
****
**
**
**
***
A10830Pracinostat
***
**
***
***
***
*
**
**
**
***
**
A11152PCI-34051
*
*
****
*
A10337Droxinostat
*
*
*
A10700Abexinostat
****
***
****
***
**
***
A13218RGFP966
**
A11037AR-42
***
A11940Ricolinostat
**
***
***
*
*
****
*
**
A11964Tacedinaline
*
*
*
**
A11153CUDC-907
****
****
****
**
*
***
**
**
****
****
A11355M344
**
A10954Tubacin
****
A13139RG2833
***
****
A12556Resminostat
***
***
**
A15489BRD73954
*
***
**
A11361BG45
*
*
**
A143544SC-202
*
*
*
A16431CAY10603
**
****
A14341LMK-235
***
****
A14032Nexturastat A
****
A14128TMP269
**
**
***
***
A14197HPOB
*
*
*
***
*
*
A12722Scriptaid
A12616Tasquinimod
A11042Tubastatin A
***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

产品 1 到 50 共 88个

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  1. CUDC-101
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    CUDC-101

    Catalog No. A10246
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    HDAC 抑制剂
    CUDC-101是一种抑制多种靶标的新型化合物，旨在抑制HDAC，EGFR和Her2。 了解更多
  2. ITF2357 (Givinostat)
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    ITF2357 (Givinostat)

    Catalog No. A10488
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    HDAC 抑制剂
    ITF2357 (Givinostat)是一种HDACS抑制剂，具有潜在的抗炎、抗血管生成和抗肿瘤活性。 了解更多
  3. Droxinostat
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    Droxinostat

    Catalog No. A10337
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    HDAC 抑制剂
    Droxinostat是HDAC3，HDAC6和HDAC8的选择性抑制剂，显示出可比较的HDAC6和HDAC8抑制作用，IC50分别为2.47和1.46μmol/ L。 了解更多
  4. PCI-24781 (Abexinostat)
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    PCI-24781 (Abexinostat)

    Catalog No. A10700
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    HDAC 抑制剂
    PCI-24781 (Abexinostat)是一种广谱苯基异羟肟酸HDAC抑制剂。 了解更多
  5. Tubastatin A HCl
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    Tubastatin A HCl

    Catalog No. A11042
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    HDAC6 抑制剂
    Tubastatin A HCl是一种有效的选择性HDAC6抑制剂，在无细胞试验中IC50为15 nM。它对除HDAC8（57倍）以外的所有其他同工酶（1000倍）具有选择性。 了解更多
  6. Pyroxamide (NSC 696085)
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    Pyroxamide (NSC 696085)

    Catalog No. A10764
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    HDAC 抑制剂
    Pyroxamide (NSC 696085)是亲和纯化的HDAC1的有效抑制剂，可导致乙酰化核心组蛋白在用该试剂培养的MEL细胞中积累。 了解更多
  7. PCI-34051
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    PCI-34051

    Catalog No. A11152
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    HDAC 抑制剂
    PCI-34051是一种有效的特异性组蛋白脱乙酰基酶8（HDAC8）抑制剂，其选择性是其他HDAC亚型的200倍以上。 了解更多
  8. Parthenolide ((-)-Parthenolide)
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    Parthenolide ((-)-Parthenolide)

    Catalog No. A10698
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    Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂，可特异性地耗尽HDAC1蛋白，而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。 了解更多
  9. Tubacin
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    Tubacin

    Catalog No. A10954
    HDAC6 抑制剂
    Tubacin (tubulin acetylation inducer)是一种高效且选择性强，可逆，可透过细胞的HDAC6抑制剂，IC50为4 nM。 了解更多
  10. LAQ824 (NVP-LAQ824, Dacinostat)
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    LAQ824 (NVP-LAQ824, Dacinostat)

    Catalog No. A10516
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    HDAC 抑制剂
    LAQ824 (NVP-LAQ824)是一种有效的新型组蛋白去乙酰化酶抑制剂，具有显著的抗多发性骨髓瘤活性。 了解更多
  11. ACY-1215 (Rocilinostat)
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    ACY-1215 (Rocilinostat)

    Catalog No. A11940
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    HDAC6 抑制剂
    ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂，从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统，并防止随后的总蛋白降解。 了解更多
  12. CI994 (Tacedinaline)
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    CI994 (Tacedinaline)

    Catalog No. A11964
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    HDAC 抑制剂
    CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。 了解更多
  13. Apicidin
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    Apicidin

    Catalog No. A12745
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    HDAC 抑制剂
    Apicidin是一种有效的组蛋白脱乙酰基酶（HDAC）抑制剂，具有潜在的抗癌活性。 了解更多
  14. RGFP966
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    RGFP966

    Catalog No. A13218
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    HDAC3 抑制剂
    RGFP966是一种HDAC3抑制剂，IC50为0.08μM，与其他HDAC相比，具有> 200倍的选择性。 了解更多
  15. BRD9757
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    BRD9757

    Catalog No. A12911
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    HDAC6 抑制剂
    BRD9757是一种高效且选择性的HDAC6抑制剂，对HDAC6的IC50为30 nM。 了解更多
  16. Resminostat
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    Resminostat

    Catalog No. A12556
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    HDAC 抑制剂
    Resminostat，也称为RAS2410，是一种有效的I和II类组蛋白脱乙酰基酶（HDAC）抑制剂。它结合并抑制HDAC，从而导致高度乙酰化的组蛋白的积累。选择性的抑制HDAC1/3/6，IC50为42.5 nM/50.1 nM/71.8 nM，作用于HDAC8效果弱，IC50为877 nM。 了解更多
  17. Scriptaid
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    Scriptaid

    Catalog No. A12722
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    HDAC 抑制剂
    Scriptaid是一种HDAC抑制剂（组蛋白脱乙酰基酶）。 了解更多
  18. Nexturastat A
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    Nexturastat A

    Catalog No. A14032
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    HDAC6 抑制剂
    Nexturastat A是一种芳基脲衍生物，可作为组蛋白脱乙酰基酶6（HDAC6）的有效且高度选择性的抑制剂（IC50 = 5.02+/-0.60 nM）。 了解更多
  19. HPOB
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    HPOB

    Catalog No. A14197
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    HDAC6 抑制剂
    HPOB是组蛋白去乙酰化酶6(HDAC6；IC50 = 56 nM)。 了解更多
  20. Splitomicin
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    Splitomicin

    Catalog No. A14221
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    NAD(+)-dependent histone deacetylase Sir2p 抑制剂
    Splitomicin是一种选择性的NAD(+)-依赖性组蛋白脱乙酰基酶Sir2p抑制剂，IC50为60 uM，在基于细胞的测定中显示出更高的活性。 了解更多
  21. Tasquinimod
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    Tasquinimod

    Catalog No. A12616
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    HDAC4 抑制剂
    Tasquinimod是一种变构抑制HDAC4信号传导的口服活性抗血管生成剂。 了解更多
  22. Santacruzamate A
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    Santacruzamate A

    Catalog No. A14236
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    HDAC 抑制剂
    Santacruzamate A (CAY10683)是一种有效的选择性HDAC抑制剂，对HDAC2的IC50为119 pM，选择性是其他HDAC的3600倍以上。 了解更多
  23. LMK-235
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    LMK-235

    Catalog No. A14341
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    HDAC4/5 抑制剂
    LMK-235是选择性组蛋白脱乙酰基酶(HDAC) 4和HDAC5抑制剂。 了解更多
  24. ST7612AA1
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    ST7612AA1

    Catalog No. A14418
    HDAC 抑制剂
    ST7612AA1是新型的有效HDAC抑制剂，具有潜在的抗癌活性。 了解更多
  25. Domatinostat (4SC-202)
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    Domatinostat (4SC-202)

    Catalog No. A14354
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    HDAC 抑制剂
    4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶（HDACs）同工酶1、2和3的抑制剂，具有潜在的抗肿瘤活性。 了解更多
  26. TMP 195
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    TMP 195

    Catalog No. A14326
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    HDAC 抑制剂
    TMP195是最有效和选择性的IIa类HDAC抑制剂。 了解更多
  27. BRD73954
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    BRD73954

    Catalog No. A15489
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    HDAC 抑制剂
    BRD73954是一种小分子抑制剂，可有效抑制HDAC6和HDAC8（IC50分别为36和120 nM）。 了解更多
  28. UF010
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    UF010

    Catalog No. A15781
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    HADC 抑制剂
    UF010是一种有效的选择性HADC抑制剂，对于HDAC 3、2、1和8分别具有IC50?0.06 uM，0.1 uM，0.5 uM和1.5 uM。它的选择性是其他HDAC的6倍以上。 了解更多
  29. HDAC inhibitor
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    HDAC inhibitor

    Catalog No. A13405
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    HDAC 抑制剂
    N/A 了解更多
  30. CAY10603
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    CAY10603

    Catalog No. A16431
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    HDAC6 抑制剂
    CAY10603是一种有效的选择性HDAC6抑制剂，IC50为2 pM，选择性是其他HDAC的200倍以上。 了解更多
  31. SR-4370
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    SR-4370

    Catalog No. A16899
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    HDAC 抑制剂
    SR-4370是HDAC抑制剂。SR-4370对HDAC1，HDAC2和HDAC3的IC50值分别为0.5 uM，0.1 uM和0.06 uM。 了解更多
  32. HDAC8-IN-1
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    HDAC8-IN-1

    Catalog No. A17091
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    HDAC8 抑制剂
    HDAC8-IN-1是一种HDAC8抑制剂，在癌细胞系中的IC50为27.2 nM。 了解更多
  33. Tinostamustine (EDO-S101)
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    Tinostamustine (EDO-S101)

    Catalog No. A18342
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    HDAC inhibitor
    EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. 了解更多
  34. SKLB-23bb
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    SKLB-23bb

    Catalog No. A18339
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    HDAC6 inhibitor
    SKLB-23bb is a potent and selective inhibitor for HDAC6 with an IC50 of 17 nM and shows 25-fold and 200-fold selectivity relative to HDAC1 (IC50=422 nM) and HDAC8 (IC50=3398 nM), respectively. 了解更多
  35. Valproic acid
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    Valproic acid

    Catalog No. A17323
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    HDAC inhibitor
    Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多
  36. Tucidinostat (Chidamide)
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    Tucidinostat (Chidamide)

    Catalog No. A17861
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    HDAC inhibitor
    Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less active on HDAC8 and HDAC11 (IC50s, 733 nM, 432 nM, respectively), and shows no effect on HDAC4/5/6/7/9. 了解更多
  37. CM-675
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    CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. 了解更多
  38. SIS-17
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    SIS-17

    Catalog No. A18463
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    HDAC 11 inhibitor
    SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. 了解更多
  39. AES-135
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    AES-135

    Catalog No. A19087
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    HDAC inhibitor
    AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 with IC50s of 654, 190, and 636 nM, respectively. Anti-tumor activity. 了解更多
  40. MPT0E028
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    MPT0E028

    Catalog No. A18982
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    HDAC inhibitor
    MPT0E028 is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. 了解更多
  41. SS-208
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    SS-208

    Catalog No. A18952
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    HDAC6 inhibitor
    SS-208 is a selective HDAC6 inhibitor, with an IC50 of 12 nM. SS-208 possesses anti-tumor activity in melanoma. 了解更多
  42. SW-100
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    SW-100

    Catalog No. A18947
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    HDAC6 inhibitor
    SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. 了解更多
  43. CHDI-390576
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    CHDI-390576

    Catalog No. A18899
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    HDAC inhibitor
    CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histonedeacetylase (HDAC) inhibitor with IC50s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform. 了解更多
  44. ACY-775
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    ACY-775

    Catalog No. A12456
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    HDAC6 inhibitor
    ACY-775 is a potent and selective inhibitor of the of histone deacetylase 6 (HDAC6) with an IC50 of 7.5?nM. 了解更多
  45. Remetinostat
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    Remetinostat

    Catalog No. A12149
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    HDAC inhibitor
    Remetinostat (SHP-141) is a hydroxamic acid-based inhibitor of histone deacetylase enzymes (HDAC) which is under development for the treatment of cutaneous T-cell lymphoma. 了解更多
  46. CXD101
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    CXD101

    Catalog No. A12253
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    HDAC inhibitor
    CXD101 is a class I-selective HDAC inhibitor (HDAC1 (IC50, 63 nM), HDAC2 (IC50, 570 nM), HDAC3 (IC50, 550 nM). CXD101 has no activity against HDAC class II. 了解更多
  47. BRD-6929
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    BRD-6929

    Catalog No. A12511
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    HDAC1/HDAC2 inhibitor
    BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. 了解更多
  48. HDACs/mTOR Inhibitor 1
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    HDACs/mTOR Inhibitor 1

    Catalog No. A13462
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    HDACs/mTOR Inhibitor 1
    HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. 了解更多
  49. MS-275 (Entinostat)
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    MS-275 (Entinostat)

    Catalog No. A10611
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    HDAC 抑制剂
    MS-275 (Entinostat)是一种有效的HDAC抑制剂，对HDAC1和HDAC3的IC50分别为0.3和8uM。 了解更多
  50. Trichostatin-A (TSA)
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    Trichostatin-A (TSA)

    Catalog No. A10947
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    HDAC 抑制剂
    Trichostatin-A (TSA)是抑制HDAC 1、3、4、6和10，IC50值约为20 nM。 了解更多

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