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IACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.22 mL | 131.11 mL | 262.23 mL |
| 0.5 mM | 5.24 mL | 26.22 mL | 52.45 mL |
| 1 mM | 2.62 mL | 13.11 mL | 26.22 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
*The above data is based on the productmolecular weight 381.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21555 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 381.35 |
| Formula | C17H18F3N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2239305-67-8 |
| Synonyms | IDO/TDO Inhibitor (R-enantiomer); IACS8968, IACS 8968 |
| SMILES | O=C(N1)N[C@]2(C(C)(C)CN(C3=CC(C(F)(F)F)=CC4=CN=CN34)CC2)C1=O |
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