Idasanutlin (RG7388)
目录号: A14211
MDM2/p53 抑制剂
Idasanutlin 是一种强效且选择性的 p53-MDM2 抑制剂。
Discription | Idasanutlin is a potent and selective p53-MDM2 inhibitor. | |||||
---|---|---|---|---|---|---|
Targets |
|
|||||
Cell Research |
|
目录号 | A14211 |
---|---|
分子式 | C31H29Cl2F2N3O4 |
分子量 | 616.48 |
CAS号 | 1229705-06-9 |
SMILES | CC(C)(C)C[C@H]1[C@]([C@H]([C@@H](N1)C(=O)NC2=C(C=C(C=C2)C(=O)O)OC)C3=C(C(=CC=C3)Cl)F)(C#N)C4=C(C=C(C=C4)Cl)F |
其他名称 | RG-7388 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 88 mg/mL (142.74 mM) | |
Water | Insoluble | ||
Ethanol | Warmed: 7 mg/mL (11.35 mM) | ||
In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 6.1 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 16.22 mL | 81.11 mL | 162.21 mL |
0.5 mM | 3.24 mL | 16.22 mL | 32.44 mL |
1 mM | 1.62 mL | 8.11 mL | 16.22 mL |
5 mM | 0.32 mL | 1.62 mL | 3.24 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2