IGF-1R

Inhibitory Selectivity

Catalog No.	Inhibitor Name	IGF-1R	Insulin Receptor	Other
A11053	Linsitinib	***	**	IRR
A11021	NVP-AEW541	**	**	FLT3,Tek,FLT1
A10440	GSK1904529A	***	***	IKK3,VEGFR2,Syk
A10658	NVP-ADW742	*
A11054	BMS-536924	**	***	FAK,MEK,LCK
A11400	AG-1024	*	*
A11175	GSK1838705A	***	****	ALK,RSK1,JNK3
A11059	BMS-754807	****	****	TrkB,Met,TrkA
A11951	PQ 401	*
A12195	Picropodophyllin	****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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XL-228

Catalog No. A13069
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IGF-1R, Aurora, FGFR, ABL, SRC 抑制剂

XL228是靶向IGF1R，AURORA激酶，FGFR1-3，ABL和SRC家族激酶的蛋白激酶抑制剂。XL228是一种Aurora A抑制剂（IC50，f3 nmol/L），对ABL1（Ki，5 nmol/L）以及BCR-ABL1 T315I（Ki，1.4 nmol/L）激酶显示出有效的生化活性。了解更多

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