Imatinib Mesylate

Name: Imatinib Mesylate
SKU: A10468

目录号: A10468

Bcr-Abl 抑制剂

Product Citations (2)

Imatinib Mesylate Chemical Structure

CAS NO. 220127-57-1

Imatinib mesylate是一种选择性酪氨酸激酶抑制剂，通过抑制KIT信号转导途径，在治疗胃肠间质瘤中诱导了持续的客观反应。

库存：现货

规格	价格	数量
100 mg	￥ 420.00
200 mg	￥ 490.00
500 mg	￥ 560.00
10mM * 1mL in DMSO	￥ 350.00

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产品详情

生物活性

Imatinib mesylate是一种选择性酪氨酸激酶抑制剂，通过抑制KIT信号转导途径，在治疗胃肠间质瘤中诱导了持续的客观反应。

靶点信息

PDGFR (Cell-free assay)	c-Kit (M-07e cells)	v-Abl (Cell-free assay)
100 nM	100 nM	600 nM

溶解度 *

In vitro	DMSO	101 mg/mL (171.26 mM)
	Water	101 mg/mL (171.26 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.96 mL	84.79 mL	169.58 mL
0.5 mM	3.39 mL	16.96 mL	33.92 mL
1 mM	1.7 mL	8.48 mL	16.96 mL
5 mM	0.34 mL	1.7 mL	3.39 mL

*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10468
作用机制	Inhibitor (抑制剂)
M. Wt	589.7
Formula	C29H31N7O.CH4SO3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	220127-57-1
Synonyms	Gleevec, Glivec, CGP-57148B, STI-571
SMILES	CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O