CXCR

Inhibitory Selectivity

Catalog No.	Inhibitor Name	CXCR1	CXCR2	CXCR4	Other
A10913	Plerixafor 8HCl			**	CXCL12-mediated chemotaxis
A13074	Plerixafor			**	CXCL12-mediated chemotaxis
A12588	WZ811			****
A14209	SB225002		***
A16351	ATI-2341			*
A14997	AMD-070 HCl			***
A15234	SCH 563705	****	***
A14209	SB225002		***
A11555	SCH-527123 (Navarixin)	**	***
A12383	Reparixin	****	**		CXCL8
A12596	MSX-122			***
A11315	AMD 070			***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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ATI-2341

Catalog No. A16351
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CXCR4 激动剂

ATI-2341是针对C-X-C趋化因子受体4型（CXCR4）（EC50 = 194 nM）的pepducin，是一种变构激动剂，可激活抑制性异三聚体G蛋白（Gi），从而促进cAMP生成的抑制并诱导钙动员。了解更多

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