INCB018424 (Ruxolitinib)

Name: INCB018424 (Ruxolitinib)
SKU: A11041
Price: 315 CNY
Rating: 5 (7 reviews)

目录号: A11041

JAK1/2 抑制剂

7 篇发表文献

INCB018424 是一种强效且选择性的 Janus-associated kinase (JAK) 1 和 2 抑制剂，其半抑制浓度（IC50）分别为 JAK1 2.7 nM、JAK2 4.5 nM 和 JAK3 332 nM。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥420.00	现货
25mg	¥595.00	现货
50mg	¥770.00	现货
100mg	¥1,050.00	现货
200mg	¥1,750.00	现货
500mg	¥3,010.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of INCB018424 (Ruxolitinib)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用INCB018424 (Ruxolitinib)发表的7篇文献

Meenu Kesarwani, .et al. , Blood Adv, 2024, Jun 11;8(11):2765-2776 PMID: 38531054

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

Rasmus Siersbek, .et al. , Cancer cell, 2020, Jul 6;S1535-6108(20)30311-1 PMID: 32679107

Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Kagoya Y, .et al. , Blood., 2014, Nov 6;124(19):2996-3006 PMID: 25217696

生物活性

Discription

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11041
分子式	C17H18N6
分子量	306.4
CAS号	941678-49-5
SMILES	C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
其他名称	Ruxolitinib, INCB18424
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	59 mg/mL (192.57 mM)
	Water	Insoluble
	Ethanol	59 mg/mL (192.57 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.64 mL	163.19 mL	326.37 mL
0.5 mM	6.53 mL	32.64 mL	65.27 mL
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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