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INCB018424 (Ruxolitinib)是有效和选择性的Janus相关激酶JAK1/2抑制剂，对JAK1，JAK2和JAK3的IC50分别为2.7、4.5和332 nM。
| In vitro (25°C) | DMSO | 59 mg/mL (192.57 mM) | |
| Water | Insoluble | ||
| Ethanol | 59 mg/mL (192.57 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.64 mL | 163.19 mL | 326.37 mL |
| 0.5 mM | 6.53 mL | 32.64 mL | 65.27 mL |
| 1 mM | 3.26 mL | 16.32 mL | 32.64 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11041 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 306.4 |
| Formula | C17H18N6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 941678-49-5 |
| Synonyms | Ruxolitinib, INCB18424 |
| SMILES | C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
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