Capmatinib (INCB28060)

Name: Capmatinib (INCB28060)
SKU: A11132
Price: 245 CNY
Rating: 5 (2 reviews)

目录号: A11132

c-MET 抑制剂

2 篇发表文献

INCB28060 是一种新型的 c-MET 激酶抑制剂。INCB28060 表现出皮克摩尔级的酶活性效力，并且对 c-MET 具有极高的特异性，其选择性比其他大量人类激酶高出超过 10,000 倍。这种抑制剂有效阻断 c-MET 磷酸化以及在依赖 c-MET 的肿瘤细胞系中其关键下游效应因子的激活。

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Grouped product items
规格	价格	库存
5mg	¥245.00	现货
10mg	¥385.00	现货
25mg	¥490.00	现货
50mg	¥630.00	现货
100mg	¥875.00	现货
200mg	¥1,120.00	现货
500mg	¥1,925.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Capmatinib (INCB28060)发表的2篇文献

Liyanage Manosika Buddhini Perera, .et al. , Biol Pharm Bull, 2024, 47(4):750-757 PMID: 38556260

Geoffrey A Pettitt, .et al. , J Pathol, 2023, Feb;259(2):220-232 PMID: 36385700

生物活性

Discription

INCB28060, a novel inhibitor of c-MET kinase. INCB28060 exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10,000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11132
分子式	C23H17FN6O
分子量	412.4
CAS号	1029712-80-8
SMILES	CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F
其他名称	INCB-28060, INC-280, INC280
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	2 mg/mL (4.84 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.25 mL	121.24 mL	242.48 mL
0.5 mM	4.85 mL	24.25 mL	48.5 mL
1 mM	2.42 mL	12.12 mL	24.25 mL
5 mM	0.48 mL	2.42 mL	4.85 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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