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INCB28060 (Capmatinib )是一种新型的，ATP竞争性c-MET抑制剂，无细胞试验中IC50为0.13 nM，对RONβ，EGFR和HER-3无活性。
靶点信息
| c-Met (Cell-free assay) | ||||
| 0.13 nM |
| In vitro | DMSO | 2 mg/mL (4.84 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.25 mL | 121.24 mL | 242.48 mL |
| 0.5 mM | 4.85 mL | 24.25 mL | 48.5 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.25 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.85 mL |
*The above data is based on the productmolecular weight 412.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11132 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 412.4 |
| Formula | C23H17FN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1029712-80-8 |
| Synonyms | INCB-28060, INC-280, INC280 |
| SMILES | CNC(=O)C1=C(C=C(C=C1)C2=NN3C(=CN=C3N=C2)CC4=CC5=C(C=C4)N=CC=C5)F |
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