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INCB39110 (Itacitinib)是一种有效的JAK1酪氨酸激酶抑制剂，目前正在II期试验中，用于治疗类风湿关节炎，骨髓纤维化，类风湿关节炎和斑块状牛皮癣。
| In vitro | DMSO | 88 mg/mL (158.98 mM) | |
| Water | Insoluble | ||
| Ethanol | 88 mg/mL (158.98 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.07 mL | 90.33 mL | 180.67 mL |
| 0.5 mM | 3.61 mL | 18.07 mL | 36.13 mL |
| 1 mM | 1.81 mL | 9.03 mL | 18.07 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
*The above data is based on the productmolecular weight 553.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14390 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 553.51 |
| Formula | C26H23F4N9O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1334298-90-6 |
| Synonyms | INCB 39110, INCB-39110, INCB039110, INCB-039110, INCB 039110 |
| SMILES | N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1 |
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