Isosorbide dinitrate
目录号: A17565
Nitric oxide donor
异山梨酯二硝酸酯是一种有机硝酸酯和一氧化氮（NO）供体，与硝酸甘油属于同一类。在小鼠异种移植模型中，异山梨酯二硝酸酯能增加肿瘤组织的氧合。它还能在体外和体内抑制血小板聚集，浓度在微摩尔范围内。含有异山梨酯二硝酸酯的制剂已被用于治疗心绞痛。
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生物活性
| Discription | Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris. |
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产品信息
| 目录号 | A17565 |
|---|---|
| 分子式 | C6H8N2O8 |
| 分子量 | 236.13 |
| CAS号 | 87-33-2 |
| SMILES | O=[N+]([O-])O[C@H]1[C@@H](OC[C@H]2O[N+]([O-])=O)[C@@H]2OC1 |
| 其他名称 | Isosorbide dinitrate; Disorlon; NSC 80038; NSC-80038; NSC80038; SST-101; Dilatrate SR; Korodil; |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 46 mg/mL (194.8 mM) | |
| Ethanol | <1 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.35 mL | 211.75 mL | 423.5 mL |
| 0.5 mM | 8.47 mL | 42.35 mL | 84.7 mL |
| 1 mM | 4.23 mL | 21.17 mL | 42.35 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.47 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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