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ITF2357 (Givinostat)

ITF2357 (Givinostat)

Name: ITF2357 (Givinostat)
SKU: A10488

目录号: A10488

HDAC 抑制剂

ITF2357 (Givinostat) Chemical Structure

CAS NO. 732302-99-7

ITF2357 (Givinostat)是一种HDACS抑制剂，具有潜在的抗炎、抗血管生成和抗肿瘤活性。

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 1,120.00
50 mg	￥ 3,150.00
100 mg	￥ 5,250.00
10mM * 1mL in DMSO	￥ 1,015.00

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生物活性

ITF2357 (Givinostat)是一种HDACS抑制剂，具有潜在的抗炎、抗血管生成和抗肿瘤活性。

靶点信息

HD1-B (Cell-free assay)	HD2 (Cell-free assay)	HD1-A (Cell-free assay)
7.5 nM	10 nM	16 nM

溶解度 *

In vitro (25°C)	DMSO	94 mg/mL (197.49 mM)
	Water	Insoluble
	Ethanol	3 mg/mL
In vivo	5%DMSO+40%PEG300++5%Tween80+50%ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.01 mL	105.04 mL	210.08 mL
0.5 mM	4.2 mL	21.01 mL	42.02 mL
1 mM	2.1 mL	10.5 mL	21.01 mL
5 mM	0.42 mL	2.1 mL	4.2 mL

*The above data is based on the productmolecular weight 476.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10488
作用机制	Inhibitor (抑制剂)
M. Wt	476.0
Formula	C24H27N3O4.HCl.H2O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	732302-99-7
Synonyms	Gavinostat
SMILES	CC[NH+](CC)CC1=CC2=C(C=C1)C=C(C=C2)COC(=O)NC3=CC=C(C=C3)C(=O)NO.O.[Cl-]