IWP-3

Name: IWP-3
SKU: A13192
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A13192

Wnt 抑制剂

IWP-3 是一种抑制 Wnt 产生的抑制剂。在体外阻断 Wnt 通路活性（IC50 = 40 nM）。IWP-3 使 Porcupine (Porcn) 失活，Porcn 是一种膜结合的 O-酰基转移酶，负责对 Wnt 蛋白进行棕榈酰化，这对它们的信号传导能力和分泌至关重要。通过阻断 Wnt 信号传导，IWP-3 已被用于促进从人类胚胎干细胞生成心肌细胞（EC50 = 1.2 µM）。

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
5mg	¥560.00	现货
10mg	¥1,050.00	现货
25mg	¥2,240.00	现货
50mg	¥3,710.00	现货
100mg	¥6,020.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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Data Sheet

SDS

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生物活性

Discription

IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC?????€ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?????€ = 1.2 μM).

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A13192
分子式	C22H17FN4O2S3
分子量	484.59
CAS号	687561-60-0
SMILES	O=C(CSC(N1C2=CC=C(F)C=C2)=NC3=C(SCC3)C1=O)NC4=NC5=C(C=C(C)C=C5)S4
其他名称	IWP 3,IWP3
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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