IWR-1-endo

Name: IWR-1-endo
SKU: A12737
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A12737

Wnt 抑制剂

1 篇发表文献

IWR-1-endo 是一种强效的 Wnt 反应抑制剂，能够阻断基于细胞的 Wnt/β-catenin 通路报告响应，其 IC50 值为 180 nM。Wnt 蛋白绑定到细胞表面的受体上，启动信号级联，导致 β-catenin 激活基因转录。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥455.00	现货
25mg	¥1,015.00	现货
50mg	¥1,715.00	现货
100mg	¥3,010.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用IWR-1-endo发表的1篇文献

Charles A.Herring, .et al. , Cell, 2022, Oct 27;S0092-8674(22)01258-2 PMID: 36318921

生物活性

Discription

IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12737
分子式	C25H19N3O3
分子量	409.44
CAS号	1127442-82-3
SMILES	C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	19 mg/mL (46.4 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.42 mL	122.12 mL	244.24 mL
0.5 mM	4.88 mL	24.42 mL	48.85 mL
1 mM	2.44 mL	12.21 mL	24.42 mL
5 mM	0.49 mL	2.44 mL	4.88 mL

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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