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JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.17 mL | 95.86 mL | 191.72 mL |
| 0.5 mM | 3.83 mL | 19.17 mL | 38.34 mL |
| 1 mM | 1.92 mL | 9.59 mL | 19.17 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.83 mL |
*The above data is based on the productmolecular weight 521.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18821 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 521.59 |
| Formula | C26H32FN9O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2091134-35-7 |
| SMILES | O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C |
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