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Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.22 mL | 171.09 mL | 342.17 mL |
| 0.5 mM | 6.84 mL | 34.22 mL | 68.43 mL |
| 1 mM | 3.42 mL | 17.11 mL | 34.22 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
*The above data is based on the productmolecular weight 292.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20153 |
|---|---|
| M. Wt | 292.25 |
| Formula | C12H12N4O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 22242-96-2 |
| Synonyms | 7-CN-7-C-Ino |
| SMILES | O=C1C2=C(N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=C2C#N)N=CN1 |
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