JKC363

Name: JKC363
SKU: A23436
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A23436

MC4 receptor antagonist

JKC363 是一种选择性的黑色素皮质素 MC4 受体拮抗剂，在 MC4 受体上的亲和力比 MC3 受体高出 90 倍（IC50=0.5 nM 对比 44.9 nM）。JKC-363 阻断了 α-MSH 对 TRH 释放的刺激作用。具有抗高敏感性效果。

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规格	价格	库存
1mg	¥280.00	现货
5mg	¥945.00	现货
10mg	¥1,610.00	现货
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生物活性

Discription	JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.

产品信息

目录号	A23436
分子式	C69H91N19O16S2
分子量	1506.71
CAS号	436083-30-6
Sequence	{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)
Sequence shortening	{Mpa}-EH-{D-2-Nal}-RWGCPPKD-NH2 (Disulfide bridge:Mpa1-Cys8)

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