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JNJ-26854165是P53激活剂之一，与AraC或阿霉素协同作用，诱导P53介导的凋亡，可能为急性白血病的治疗提供新的治疗途径。
| In vitro (25°C) | DMSO | 56 mg/mL (170.51 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (6.08 mM) | ||
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.45 mL | 152.25 mL | 304.51 mL |
| 0.5 mM | 6.09 mL | 30.45 mL | 60.9 mL |
| 1 mM | 3.05 mL | 15.23 mL | 30.45 mL |
| 5 mM | 0.61 mL | 3.05 mL | 6.09 mL |
*The above data is based on the productmolecular weight 328.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10491 |
|---|---|
| 作用机制 | Activator (激活剂) |
| M. Wt | 328.4 |
| Formula | C21H20N4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 881202-45-5 |
| Synonyms | JNJ26854165, JNJ-26854165 |
| SMILES | C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4 |
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