JNJ-28312141

Name: JNJ-28312141
SKU: A12687
Price: 2415 CNY
Rating: 5 (288 reviews)

目录号: A12687

CSF1R 抑制剂

JNJ-28312141 是一种口服活性的 CSF1R 抑制剂（集落刺激因子-1 受体，CRF1R）以及 FLT3 抑制剂。CSF1R 在许多肿瘤中表达，并且是巨噬细胞的生长因子，同时介导破骨细胞的分化。JNJ-28312141 是一种新型药物，具有潜在的治疗活性，用于急性髓系白血病以及 CSF-1 依赖性巨噬细胞和破骨细胞促进肿瘤生长和骨骼事件的情况。

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规格	价格	库存
5mg	¥2,415.00	现货
10mg	¥4,515.00	现货
25mg	¥8,365.00	现货
50mg	¥13,825.00	现货
100mg	¥17,465.00	现货
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Data Sheet

SDS

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生物活性

Discription

JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12687
分子式	C26H32N6O2
分子量	460.57
CAS号	885692-52-4
SMILES	CN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4
其他名称	JNJ 28312141, JNJ28312141
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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