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JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.46 mL | 112.29 mL | 224.59 mL |
| 0.5 mM | 4.49 mL | 22.46 mL | 44.92 mL |
| 1 mM | 2.25 mL | 11.23 mL | 22.46 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.49 mL |
*The above data is based on the productmolecular weight 445.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21470 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 445.26 |
| Formula | C17H19Cl2F5N4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2108806-02-4 |
| Synonyms | JNJ37822681, JNJ 37822681 |
| SMILES | FC(C1=NN=C(NC2CCN(CC3=CC=C(F)C(F)=C3)CC2)C=C1)(F)F.Cl.Cl |
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