JNJ-64619178

Name: JNJ-64619178
SKU: A16861

目录号: A16861

Histone Methyltransferase 抑制剂

JNJ-64619178 Chemical Structure

CAS NO. 2086772-26-9

JNJ-64619178是PRMT5抑制剂，在不同的体外和细胞条件下均具有高选择性和强效性（亚纳摩尔范围，PRMT5-MEP-50 IC50 = 0.14 nM），并具有良好的药代动力学和安全性。

库存：现货

规格	价格	数量
1 mg	￥ 630.00
2 mg	￥ 980.00
5 mg	￥ 1,400.00
50 mg	￥ 7,560.00

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溶解度 *

In vitro	DMSO	94 mg/mL (194.47 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.69 mL	103.44 mL	206.88 mL
0.5 mM	4.14 mL	20.69 mL	41.38 mL
1 mM	2.07 mL	10.34 mL	20.69 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

*The above data is based on the productmolecular weight 483.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16861
作用机制	Inhibitor (抑制剂)
M. Wt	483.37
Formula	C22H23BrN6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2086772-26-9
Synonyms	JNJ64619178, JNJ 64619178
SMILES	BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1