Onametostat (JNJ-64619178)

Name: Onametostat (JNJ-64619178)
SKU: A16861
Price: 525 CNY
Rating: 5 (288 reviews)

目录号: A16861

Histone Methyltransferase 抑制剂

JNJ-64619178 是一种 PRMT5 抑制剂，具有高选择性和高效力（亚纳摩尔范围，PRMT5-MEP-50 IC50=0.14 nM），在不同的体外和细胞条件下表现出色，且具有良好的药代动力学和安全性特性。

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Grouped product items
规格	价格	库存
1mg	¥525.00	现货
2mg	¥945.00	现货
5mg	¥1,190.00	现货
10mg	¥1,960.00	现货
25mg	¥4,130.00	现货
50mg	¥6,895.00	现货
100mg	¥12,180.00	现货
*10mM 1mL in DMSO**	¥1,295.00	现货
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Data Sheet

SDS

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生物活性

Discription

JNJ-64619178 is a PRMT5 inhibitor with high selectivity and potency (subnanomolar range, PRMT5-MEP-50 IC50=0.14 nM) under different in vitro and cellular conditions, paired with favorable pharmacokinetics and safety properties.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16861
分子式	C22H23BrN6O2
分子量	483.37
CAS号	2086772-26-9
SMILES	BrC1=C(N)N=C(C=C(CC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C(N=CN=C4N)=C4C=C3)C2)C=C5)C5=C1
其他名称	JNJ64619178, JNJ 64619178
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	94 mg/mL (194.47 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.69 mL	103.44 mL	206.88 mL
0.5 mM	4.14 mL	20.69 mL	41.38 mL
1 mM	2.07 mL	10.34 mL	20.69 mL
5 mM	0.41 mL	2.07 mL	4.14 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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