JNJ-7706621

Name: JNJ-7706621
SKU: A10494
Price: 245 CNY
Rating: 5 (1 reviews)

目录号: A10494

CDK/Aurora A/B 抑制剂

1 篇发表文献

JNJ-7706621 是一种广谱 CDK 抑制剂，在 CDK1/2 上具有最高的抑制活性，其 IC50 分别为 9 nM/4 nM，并且在无细胞试验中对 CDK1/2 的选择性比 CDK3/4/6 高出6倍以上。它还强效抑制 Aurora A/B，并且对 Plk1 和 Wee1 无活性。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥385.00	现货
5mg	¥700.00	现货
10mg	¥1,260.00	现货
25mg	¥2,030.00	现货
50mg	¥3,465.00	现货
100mg	¥5,320.00	现货
500mg	¥10,815.00	现货
*10mM 1mL in DMSO**	¥595.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用JNJ-7706621发表的1篇文献

Yuta Tanizaki, .et al. , Commun Biol, 2022, 5: 112 PMID: 35132135

生物活性

Discription

JNJ-7706621 is pan-CDK inhibitor with the highest potency on CDK1/2 with IC50 of 9 nM/4 nM and showing >6-fold selectivity for CDK1/2 than CDK3/4/6 in cell-free assays. It also potently inhibits Aurora A/B and has no activity on Plk1 and Wee1.

Targets

Target	Value

产品信息

目录号	A10494
分子式	C15H12F2N6O3S
分子量	394.4
CAS号	443797-96-4
SMILES	C1=CC(=C(C(=C1)F)C(=O)N2C(=NC(=N2)NC3=CC=C(C=C3)S(=O)(=O)N)N)F
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	67 mg/mL (169.89 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.35 mL	126.77 mL	253.55 mL
0.5 mM	5.07 mL	25.35 mL	50.71 mL
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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