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JW74是典型的Wnt信号传导的有效和特异性抑制剂。JW74显示ST-Luc分析中规范Wnt信号的减少，IC50值为790 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.9 mL | 109.52 mL | 219.05 mL |
| 0.5 mM | 4.38 mL | 21.9 mL | 43.81 mL |
| 1 mM | 2.19 mL | 10.95 mL | 21.9 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
*The above data is based on the productmolecular weight 456.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16219 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 456.52 |
| Formula | C24H20N6O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 863405-60-1 |
| Synonyms | JW-74, JW 74 |
| SMILES | CC1=CC=C(C2=NOC(CSC3=NN=C(C4=CC=NC=C4)N3C5=CC=C(OC)C=C5)=N2)C=C1 |
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