KDM2A/7A-IN-1
目录号: A19724
KDM2A/7A inhibitor
KDM2A/7A-IN-1 是首创的、选择性的、细胞渗透性的组蛋白赖氨酸去甲基化酶 KDM2A/7A 抑制剂,对 KDM2A 的 IC50 为 0.16 μM,对其他 JmjC 赖氨酸去甲基化酶具有 75 倍的选择性,并且对甲基转移酶和组蛋白乙酰转移酶无活性。
Discription | KDM2A/7A-IN-1 is a first-in-class, selective and cell-permeable inhibitor of histone lysine demethylases KDM2A/7A, with an IC50 of 0.16?μM for KDM2A, exhibits 75 fold selevtivity over other JmjC lysine demethylases, and is inactive on methyl transferases, and histone acetyl transferases. |
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目录号 | A19724 |
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分子式 | C33H38N4O |
分子量 | 506.68 |
CAS号 | 2169272-46-0 |
SMILES | CC(N([C@@H](C1=CN=CC(CCCCCCCN2CCCC2)=C1)[C@@]3(C4=CC=CC=C4)C#N)C5=C3C=CC=C5)=O |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2