KP-457

目录号: A19622
ADAM17 抑制剂
KP-457 是一种选择性的 ADAM17 抑制剂(a disintegrin and metalloproteinase 17),相较于其他的 MMPsADAM10,其对 ADAM17 的选择性更高。其半抑制浓度(IC50)分别为:ADAM17 为 11.1 nM,ADAM10 为 748 nM,MMP2 为 717 nM,MMP3 为 9760 nM,MMP8 为 2200 nM,MMP9 为 5410 nM,MMP13 为 930 nM,MMP14 为 2140 nM,以及 MMP17 为 7100 nM。
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规格 价格 库存 数量
1mg
¥595.00
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5mg
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10mg
¥2,555.00
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25mg
¥4,760.00
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50mg
¥7,595.00
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100mg
¥10,325.00
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10mM * 1mL in DMSO
¥1,645.00
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  • Tolulope E Ayo, .et al. , Cell Signal, 2023, May;105:110607 PMID: 36690134
  • 生物活性
    Discription KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
    产品信息
    目录号 A19622
    分子式 C21H24N2O7S2
    分子量 480.55
    CAS号 1365803-52-6
    SMILES CS(=O)(NCC1=CC=C(C(N(C=O)O)CS(=O)(C2=CC=C(OCC#CC)C=C2)=O)C=C1)=O
    其他名称 KP457, KP 457
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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