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KP-457

KP-457

Name: KP-457
SKU: A19622

目录号: A19622

ADAM17 inhibitor

KP-457 Chemical Structure

CAS NO. 1365803-52-6

KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.

库存：现货

规格	价格	数量
1 mg	￥ 2,240.00
5 mg	￥ 6,720.00
10 mg	￥ 11,200.00

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.81 mL	104.05 mL	208.09 mL
0.5 mM	4.16 mL	20.81 mL	41.62 mL
1 mM	2.08 mL	10.4 mL	20.81 mL
5 mM	0.42 mL	2.08 mL	4.16 mL

*The above data is based on the productmolecular weight 480.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A19622
M. Wt	480.55
Formula	C21H24N2O7S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1365803-52-6
Synonyms	KP457, KP 457
SMILES	CS(=O)(NCC1=CC=C(C(N(C=O)O)CS(=O)(C2=CC=C(OCC#CC)C=C2)=O)C=C1)=O