KRN 633
目录号: A10504
VEGFR 抑制剂
KRN 633 是一种细胞渗透性、可逆的、与ATP竞争的 VEGFR激酶抑制剂，仅在较高浓度下抑制 PDGFR-α 和 c-Kit（分别为 IC50 = 0.97 μM 和 4.33 μM），对其他17种激酶无活性（IC50 > 10 μM）。
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生物活性
| Discription | KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations only (IC50 = 0.97 μM and 4.33 μM, respectively) and inactive towards 17 other kinases (IC50 ??? 10 μM). | ||
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产品信息
| 目录号 | A10504 |
|---|---|
| 分子式 | C20H21ClN4O4 |
| 分子量 | 416.9 |
| CAS号 | 286370-15-8 |
| SMILES | CCCNC(=O)NC1=C(C=C(C=C1)OC2=NC=NC3=CC(=C(C=C32)OC)OC)Cl |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 8 mg/mL (19.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% methylcellulose+0.2% Tween 80 | 9 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.99 mL | 119.93 mL | 239.87 mL |
| 0.5 mM | 4.8 mL | 23.99 mL | 47.97 mL |
| 1 mM | 2.4 mL | 11.99 mL | 23.99 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 286370-15-8 | 286370-15-8 供应商 | 286370-15-8 花费 | 286370-15-8 生产商 | 订购 286370-15-8 | 286370-15-8 代理商