KRX-0402
目录号: A15459
DNA repair inhibitor
KRX-0402 是一种小分子化合物,专门设计用于阻断 DNA 修复蛋白 MGMT。MGMT 赋予了对某些烷化剂的抗性,例如用于治疗脑癌、黑色素瘤和非霍奇金淋巴瘤的常用药物 temozolomide 和 BCNU。
Discription | KRX-0402 is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin?€?s lymphoma. |
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目录号 | A15459 |
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分子式 | C12H11N5O |
分子量 | 241.25 |
CAS号 | 1000874-21-4 |
SMILES | NC1=NC(OCC2=CC=CC=C2)=C3NC=NC3=N1 |
其他名称 | O6-benzyl guanine, O6-BG |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2