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KRX-0402是一个小分子,专门设计用于阻断DNA修复蛋白MGMT。MGMT赋予了对某些烷基化剂(如替莫唑胺和BCNU)的抗性,后者通常用于治疗脑癌,黑色素瘤和非霍奇金淋巴瘤。
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 41.45 mL | 207.25 mL | 414.51 mL |
0.5 mM | 8.29 mL | 41.45 mL | 82.9 mL |
1 mM | 4.15 mL | 20.73 mL | 41.45 mL |
5 mM | 0.83 mL | 4.15 mL | 8.29 mL |
*The above data is based on the productmolecular weight 241.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A15459 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 241.25 |
Formula | C12H11N5O |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1000874-21-4 |
Synonyms | O6-benzyl guanine, O6-BG |
SMILES | NC1=NC(OCC2=CC=CC=C2)=C3NC=NC3=N1 |
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