KU 0060648

Name: KU 0060648
SKU: A13224

目录号: A13224

DNA-PK 抑制剂

KU 0060648 Chemical Structure

CAS NO. 881375-00-4

KU0060648是一种有效且选择性的DNA依赖性蛋白激酶（DNA-PK）抑制剂（IC50 = 8.6 nM）；对DNA-PK的选择性是其他PIKK的20-1000倍，并且有60种激酶。KU-0060648可提高HDR效率并衰减NHEJ频率。

库存：现货

规格	价格	数量
5 mg	￥ 700.00
10 mg	￥ 1,260.00
25 mg	￥ 2,450.00
50 mg	￥ 4,200.00

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产品详情

溶解度 *

In vitro (25°C)	DMSO	0.39 mg/mL (0.66 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.45 mL	72.24 mL	144.49 mL
0.5 mM	2.89 mL	14.45 mL	28.9 mL
1 mM	1.44 mL	7.22 mL	14.45 mL
5 mM	0.29 mL	1.44 mL	2.89 mL

*The above data is based on the productmolecular weight 692.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13224
作用机制	Inhibitor (抑制剂)
M. Wt	692.1
Formula	C33H34N4O4S.3HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	881375-00-4
Synonyms	KU0060648, KU-0060648
SMILES	CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7