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KU-55933是ATM抑制剂，通过抑制细胞增殖，并通过阻断Akt过度激活的癌细胞中的Akt诱导凋亡。
Targets
| Target | Value |
|---|---|
| ATM | IC50: 12.9nM |
| DNA-PK | IC50: 2.5μM |
| mTOR | IC50: 9.3μM |
| PI3K | IC50: 16.6μM |
| ATR | IC50: >100μM |
| PI4K | IC50: >100μM |
| In vitro (25°C) | DMSO | 29 mg/mL (73.33 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween80+50%ddH2O | 3.75 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.28 mL | 126.42 mL | 252.84 mL |
| 0.5 mM | 5.06 mL | 25.28 mL | 50.57 mL |
| 1 mM | 2.53 mL | 12.64 mL | 25.28 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.06 mL |
*The above data is based on the productmolecular weight 395.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10506 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 395.5 |
| Formula | C21H17NO3S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 587871-26-9 |
| Synonyms | KU55933 |
| SMILES | C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4 |
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