LDE225 (NVP-LDE225, Sonidegib)

Name: LDE225 (NVP-LDE225, Sonidegib)
SKU: A10520

目录号: A10520

Smo 拮抗剂

Product Citations (1)

LDE225 (NVP-LDE225, Sonidegib) Chemical Structure

CAS NO. 956697-53-3

LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 490.00
50 mg	￥ 1,050.00
100 mg	￥ 1,750.00
10mM * 1mL in DMSO	￥ 350.00

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生物活性

LDE225 (NVP-LDE225)是一种强效、选择性和口服生物可利用的平滑(SMO)拮抗剂，通过平滑受体(SMO)的拮抗作用抑制hedgehog (Hh)信号通路。

靶点信息

Smo (mouse) (Cell-free assay)	Smo (human) (Cell-free assay)
1.3 nM	2.5 nM

溶解度 *

In vitro (25°C)	DMSO	82 mg/mL (168.89 mM)
	Water	Insoluble
	Ethanol	Warmed: 82 mg/mL (168.89 mM)
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.6 mL	102.99 mL	205.97 mL
0.5 mM	4.12 mL	20.6 mL	41.19 mL
1 mM	2.06 mL	10.3 mL	20.6 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

*The above data is based on the productmolecular weight 485.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10520
作用机制	Antagonist (拮抗剂)
M. Wt	485.5
Formula	C26H26F3N3O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	956697-53-3
Synonyms	LDE-225
SMILES	C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F