LDE225 (NVP-LDE225, Sonidegib)

Name: LDE225 (NVP-LDE225, Sonidegib)
SKU: A10520
Price: 315 CNY
Rating: 5 (1 reviews)

目录号: A10520

Smo Ant激动剂

1 篇发表文献

LDE225（NVP-LDE225）是一种强效、选择性且口服生物利用度高的平滑化蛋白（SMO）拮抗剂，通过拮抗平滑化蛋白受体（SMO）来抑制刺猬（Hh）信号通路。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥455.00	现货
25mg	¥770.00	现货
50mg	¥1,015.00	现货
100mg	¥1,715.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LDE225 (NVP-LDE225, Sonidegib)发表的1篇文献

Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

生物活性

Discription

LDE225 (NVP-LDE225) is a potent, selective and orally bioavailable Smoothened (SMO) antagonist that inhibits hedgehog (Hh) signaling pathway via antagonism of the Smoothened receptor (SMO).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10520
分子式	C26H26F3N3O3
分子量	485.5
CAS号	956697-53-3
SMILES	C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	82 mg/mL (168.89 mM)
	Water	Insoluble
	Ethanol	Warmed: 82 mg/mL (168.89 mM)
In vivo	2% DMSO+corn oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.6 mL	102.99 mL	205.97 mL
0.5 mM	4.12 mL	20.6 mL	41.19 mL
1 mM	2.06 mL	10.3 mL	20.6 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 LDE225 (NVP-LDE225, Sonidegib) | LDE225 (NVP-LDE225, Sonidegib) 供应商 | LDE225 (NVP-LDE225, Sonidegib) 花费 | LDE225 (NVP-LDE225, Sonidegib) 生产商 | 订购 LDE225 (NVP-LDE225, Sonidegib) | LDE225 (NVP-LDE225, Sonidegib) 代理商 | 购买 956697-53-3 | 956697-53-3 供应商 | 956697-53-3 花费 | 956697-53-3 生产商 | 订购 956697-53-3 | 956697-53-3 代理商