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LDK378 (Ceritinib) dihydrochloride是有效的抗ALK抑制剂，IC50为0.2 nM，对IGF-1R和InsR的选择性分别为40倍和35倍。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.82 mL | 84.09 mL | 168.18 mL |
| 0.5 mM | 3.36 mL | 16.82 mL | 33.64 mL |
| 1 mM | 1.68 mL | 8.41 mL | 16.82 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
*The above data is based on the productmolecular weight 594.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15142 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 594.6 |
| Formula | C28H37Cl2N5O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1380575-43-8 |
| Synonyms | LDK 378 dihydrochloride, LDK-378 dihydrochloride, Ceritinib dihydrochloride |
| SMILES | CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl.Cl.Cl |
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