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LDN193189 HCl (DM-3189) is the hydrochloride salt of LDN193189, which is a selective BMP signaling inhibitor, and inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM in C2C12 cell lines, respectively, 200-fold selectivity for BMP versus TGF-β.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.86 mL | 104.3 mL | 208.59 mL |
| 0.5 mM | 4.17 mL | 20.86 mL | 41.72 mL |
| 1 mM | 2.09 mL | 10.43 mL | 20.86 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.17 mL |
*The above data is based on the productmolecular weight 479.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22307 |
|---|---|
| M. Wt | 479.4 |
| Formula | C25H24Cl2N6 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 1435934-00-1 |
| Synonyms | DM-3189 2HCl |
| SMILES | N1(C2=CC=C(C(C=N3)=CN4C3=C(C5=CC=NC6=C5C=CC=C6)C=N4)C=C2)CCNCC1.Cl.Cl |
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