Letrozole

Name: Letrozole
SKU: A10523

目录号: A10523

Aromatase 抑制剂

Product Citations (1)

Letrozole Chemical Structure

CAS NO. 112809-51-5

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。

库存：现货

规格	价格	数量
10 mg	￥ 140.00
50 mg	￥ 350.00
100 mg	￥ 455.00
10mM * 1mL in DMSO	￥ 455.00

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生物活性

Letrozole是芳香酶抑制剂。CGS 20267是一种新型的非甾体化合物，在体外（IC50为11.5 nM）和在体内（ED50为1-3μg/ kg p.o.）均能有效抑制芳香化酶。

靶点信息

Aromatase (Cell-free assay)
0.07 nM-20 nM

溶解度 *

In vitro (25°C)	DMSO	50 mg/mL (175.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC Na	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.05 mL	175.25 mL	350.51 mL
0.5 mM	7.01 mL	35.05 mL	70.1 mL
1 mM	3.51 mL	17.53 mL	35.05 mL
5 mM	0.7 mL	3.51 mL	7.01 mL

*The above data is based on the productmolecular weight 285.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10523
作用机制	Inhibitor (抑制剂)
M. Wt	285.3
Formula	C17H11N5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	112809-51-5
Synonyms	CGS 20267, Femara, Piroxicam
SMILES	C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3