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Lexibulin 2Hcl (CYT-997 2Hcl) is a potent tubulin polymerisation inhibitor with IC50 of 10-100 nM in cancer cell lines; with potent cytotoxic and vascular disrupting activity in vitro and in vivo.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.71 mL | 98.53 mL | 197.06 mL |
| 0.5 mM | 3.94 mL | 19.71 mL | 39.41 mL |
| 1 mM | 1.97 mL | 9.85 mL | 19.71 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
*The above data is based on the productmolecular weight 507.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21774 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 507.46 |
| Formula | C24H32Cl2N6O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 917111-49-0 |
| Synonyms | CYT-997 dihydrochloride, CYT997, CYT 997 |
| SMILES | CCC[C@H](NC1=C(C)C=NC(C2=CC=C(NC(NCC)=O)C(OC)=C2)=N1)C3=CN=CC=C3.[H]Cl.[H]Cl |
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